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pentobarbital will reduce the extent or effect of amlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will lower the extent or effect of ibuprofen by influencing hepatic enzyme CYP2C9/ten metabolism. Slight/Significance Unidentified.pentobarbital will lessen the extent or effect of docetaxel